N-[7-Chloro-4-[4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl]quinoline]-acetamide
نویسندگان
چکیده
The 1,2,3-triazole is a well-known biologically active pharmacophore constructed by the copper-catalyzed azide–alkyne cycloaddition. We herein reported synthesis of 4-amino-7-chloro-based [1,2,3]-triazole hybrids via Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition 4-azido-7-chloroquinoline with an alkyne derivative acetaminophen. compound was fully characterized Fourier-transform infrared (FTIR), proton nuclear magnetic resonance (1H-NMR), carbon-13 (13C-NMR), heteronuclear single quantum coherence (HSQC), ultraviolet (UV) and high-resolution mass spectroscopies (HRMS). This screened in vitro different normal cancer cell lines. drug likeness also investigated predicting its pharmacokinetic properties.
منابع مشابه
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ژورنال
عنوان ژورنال: Molbank
سال: 2021
ISSN: ['1422-8599']
DOI: https://doi.org/10.3390/m1213